Traceless Ligation of Cysteine Peptides Using Selective
2019-8-23 · Staudinger 连接反应（Staudinger ligation），2000年由 Saxon 和 Bertozzi 发展。 用一般位于三芳膦上的亲电基团（如甲酯） 捕获 氮杂叶立德（亚胺基膦烷）中间体，在水介质中进行作用，重排后得到分子内酰胺基氧化膦。 The traceless Staudinger ligation for indirect 18F The Staudinger ligation of phosphine-substituted thioesters with 18F-fluoroethylazide has been successfully applied to access 18F-labelled molecules in radiochemical yields superior to 95%; the first fluorous variant of a Staudinger radio-ligation has been validated. Traceless β-mercaptan-assisted activation of … 2018-1-5 · Herein, we report a traceless ligation at Val-Xaa sites under mild thiol additive-free reaction conditions, whereby the introduction of β-mercaptan on the C-terminal valine residue effectively activates the otherwise unreactive N-acyl-benzimidazolinone (Nbz), and
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Development of a Visible Light Triggerable Traceless
2020-7-23 · Other Staudinger ligation induced macrocyclizations have been published previously by Maarseveen and co-workers, who successfully used the Raines ligation reagent for the synthesis of a series of medium-sized lactams. 4 Wong and co-workers reported the synthesis of 14 different glycopeptides through the traceless Staudinger Ligation. 5 For this work, they also developed a …
T1 - Traceless chemical ligation from S -, O -, and N-acyl isopeptides. AU - Panda, Siva S. PY - 2014/4/15. Y1 - 2014/4/15. N2 - Peptides are ubiquitous in nature where they play crucial roles as catalysts (enzymes), cell membrane ion transporters, and … traceless in Chinese | English to Chinese …